Which of the following are core symptoms of major depressive disorder?

The core symptoms of major depressive disorder include persistent sadness and a significant loss of interest or pleasure in almost all activities. These symptoms are central to the diagnosis and help distinguish major depressive disorder from other mood disorders. The feeling of sadness can manifest as a constant low mood, while the loss of interest may lead to withdrawal from social engagements, hobbies, and daily tasks that once brought joy.

This understanding aligns with the diagnostic criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), which emphasizes the importance of these symptoms in identifying major depressive disorder. Recognizing and addressing these core symptoms is crucial for effective treatment and management of the disorder, allowing mental health professionals to tailor interventions appropriately.