What important instruction should be given to a client after switching from lithium to valproic acid (Depakote)?

When a client transitions from lithium to valproic acid (Depakote), one of the crucial instructions involves the regular monitoring of liver function and hematology. Valproic acid can have significant effects on liver metabolism and may cause hepatotoxicity. Therefore, it’s essential to assess liver enzymes periodically to ensure that the medication isn’t causing any harm to the liver.

In addition to liver function, valproic acid can also affect blood cell counts, making regular laboratory monitoring important for detecting any potential hematological issues, such as thrombocytopenia (low platelet count) or leukopenia (low white blood cell count). These measures help safeguard the health of the client during their treatment and ensure that any adverse effects are identified quickly and managed appropriately.